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Frozen faecal microbiota transplantation

Clostridium difficile (CD) is the leading cause of antibiotic-associated diarrhoea, affecting mainly the elderly and those with underlying co-morbidities and is associated with 90-day mortality rates of up to 13.5%. Recurrent Clostridium difficile infection can be a serious, life-threatening condition. It can occur in patients undergoing antibiotic treatment, in particular those on broad spectrum antibiotics.

Frozen faecal microbiota transplantation (FMT) is supplied thorough the ITP programme for use in management of patients with recurrent CD infection. It is an effective alternative to antibiotic treatment for CD infection at comparable cost. The high cure rates (90%) and reduced use of antibiotics result in a win-win for patients and the NHS.

The Oxford AHSN is working with Oxford University Hospitals NHS Foundation Trust to adopt FMT and embed it into standard operating procedures.